Antidepressants are a class of drugs that reduce symptoms of depressive disorders by correcting chemical imbalances of neurotransmitters in the brain. Drug Detection Window - Drug Test School- urine drug test, saliva drug test, alcohol test, hair drug test Introduction. Dependence on and withdrawal from imipramine, the first tricyclic antidepressant was reported in 1959. It had only been introduced in 1958. Buprenorphine, sold under the brand name Subutex, among others, is an opioid used to treat opioid addiction, acute pain, and chronic pain. It can be used under the tongue, by injection, as a skin patch, or as an implant. Buprenorphine and the combination of buprenorphine and naloxone are used to treat opioid dependence (addiction to opioid drugs, including heroin and narcotic painkillers). Hydrocodone is available in combination with other ingredients, and different combination products are prescribed for different uses. Some hydrocodone combination products are used to relieve moderate-to-severe pain. Hydromorphone is an opioid agonist and therefore has abuse potential and risk of fatal overdose from depressed respiration. Addiction may occur in patients who obtain hydromorphone illicitly or in those appropriately prescribed the drug. Medical uses Methadone maintenance. Methadone is used for the treatment of opioid use disorder. It may be used as a maintenance therapy or in shorter periods for detoxification to manage opioid withdrawal symptoms. Meperidine is an opioid agonist and therefore has abuse potential and risk of fatal overdose from respiratory failure. Addiction may occur in patients who obtain meperidine illicitly or in those appropriately prescribed the drug. What is Alcohol Addiction? Alcohol addiction (alcoholism) is a physical or mental dependence on alcohol. Alcohol addiction can lead to health and social problems, and difficulty maintaining responsibilities.